{"id":3778,"date":"2026-01-29T06:33:35","date_gmt":"2026-01-29T06:33:35","guid":{"rendered":"https:\/\/sodlike.sk-ads.com\/?p=3778"},"modified":"2026-01-29T06:33:35","modified_gmt":"2026-01-29T06:33:35","slug":"car-t-immunotherapy-has-shown-poor-efficacy-in-treating-solid-tumors","status":"publish","type":"post","link":"https:\/\/sodlike.sk-ads.com\/index.php\/2026\/01\/29\/car-t-immunotherapy-has-shown-poor-efficacy-in-treating-solid-tumors\/","title":{"rendered":"\u764c\u75c7\u514d\u75ab\u7642\u6cd5CAR-T\u5c0d\u5be6\u9ad4\u764c\u7642\u6548\u4e0d\u4f73"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong><em>Nature<\/em><\/strong>, 567(7749):530-534, 2019<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u4e3b\u8981\u662f\u5f9e\u60a3\u8005\u9ad4\u5167\u5206\u96e2\u51faT\u7d30\u80de\uff0c\u5728\u9ad4\u5916\u5229\u7528\u5d4c\u5408\u6297\u539f\u53d7\u9ad4\uff08CAR\uff09\u4fee\u98feT\u7d30\u80de\uff0c\u4f7f\u5176\u80fd\u5920\u7279\u7570\u6027\u8b58\u5225\u764c\u7d30\u80de\uff0c\u7136\u5f8c\u518d\u5c07\u6539\u9020\u5f8c\u7684T\u7d30\u80de\u64f4\u589e\u3001\u56de\u8f38\u81f3\u60a3\u8005\u9ad4\u5167\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f46\u662f\uff0c\u5728\u9762\u5c0d\u5be6\u9ad4\u7624\u6642\uff0cCAR-T\u7642\u6cd5\u5b58\u5728\u4e00\u500b\u7f3a\u9ede\uff0c\u90a3\u5c31\u662f\u9032\u5165\u5be6\u9ad4\u7624\u4e2d\u7684T\u7d30\u80de\u53ef\u80fd\u6703\u56e0\u70ba\u4e00\u7a2e\u300cT\u7d30\u80de\u8870\u7aed\u300d\uff08T cell exhaustion\uff09\u7684\u73fe\u8c61\u800c\u505c\u6b62\u5de5\u4f5c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u800c\u70ba\u4f55\u6703\u6709\u300cT\u7d30\u80de\u8870\u7aed\u300d\u7684\u73fe\u8c61\u767c\u751f\u5462\uff1f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7f8e\u570b\u52a0\u5dde\u514d\u75ab\u5b78\u7814\u7a76\u6240\uff08LJI\uff09\u767c\u8868\u5728\u300aNature\u300b\u671f\u520a\u4e0a\u7684\u7814\u7a76\u767c\u73fe\uff0c\u4e00\u7a2e\u540d\u70baNr4a \u7684\u8f49\u9304\u56e0\u5b50\u5bb6\u65cf\uff0c\u5728\u9020\u6210T\u7d30\u80de\u8870\u7aed\u7684\u904e\u7a0b\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u7f79\u764c\u5c0f\u9f20\u70ba\u9032\u884c\u5be6\u9a57\u767c\u73fe\uff0c\u7576\u7f3a\u4e4fNr4a\u8f49\u9304\u56e0\u5b50\u6642\uff0cCAR-T\u6cbb\u7642\u6548\u679c\u66f4\u4f73\uff0c\u53ef\u4ee5\u8b93\u816b\u7624\u9ad4\u7a4d\u6e1b\u5c0f\uff0c\u60a3\u764c\u5c0f\u9f20\u751f\u5b58\u7387\u63d0\u9ad8\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u7576T\u7d30\u80de\u9762\u81e8\u6162\u6027\u75c5\u6bd2\u611f\u67d3\u6642\uff0cNr4a\u7684\u542b\u91cf\u6703\u4e0a\u5347\u3002\u800c\u66b4\u9732\u65bc\u6162\u6027\u75c5\u6bd2\u6297\u539f\u6642\u9593\u6108\u4e45\uff0cT\u7d30\u80de\u5c31\u6703\u51fa\u73fe\u300c\u75b2\u5026\u300d\u7684\u72c0\u6cc1\uff0c\u6700\u5f8c\u5c31\u662f\u8b8a\u6210\u300c\u505c\u6b62\u5de5\u4f5c\u300d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9019\u9805\u7814\u7a76\u78ba\u8a8d\u4e86\u9020\u6210T\u7d30\u80de\u8870\u7aed\u7684\u95dc\u9375\u56e0\u5b50\uff0c\u96d6\u7136\u76ee\u524d\u7121\u6cd5\u76f4\u63a5\u61c9\u7528\u65bcCAR-T\u6cbb\u7642\u5be6\u9ad4\u7624\u7684\u81e8\u5e8a\u7814\u7a76\u4e2d\uff0c\u4f46\u7b49\u65bc\u662f\u89e3\u958b\u4e86\u4e00\u500b\u514d\u75ab\u5b78\u8b0e\u5718\uff0c\u4e5f\u70ba\u79d1\u5b78\u5bb6\u5011\u63d0\u4f9b\u4e86\u4e00\u500b\u8a2d\u8a08\u66f4\u597d\u6297\u764c\u7b56\u7565\u7684\u65b0\u7dda\u7d22\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature, 567(7749):530-534, 2019 CAR-T\u7642\u6cd5\u4e3b\u8981\u662f\u5f9e\u60a3\u8005\u9ad4\u5167\u5206\u96e2\u51faT\u7d30\u80de\uff0c\u5728\u9ad4\u5916\u5229\u7528\u5d4c\u5408\u6297\u539f\u53d7\u9ad4\uff08CAR\uff09\u4fee\u98feT\u7d30\u80de\uff0c\u4f7f\u5176\u80fd\u5920\u7279\u7570\u6027\u8b58\u5225\u764c\u7d30\u80de\uff0c\u7136\u5f8c\u518d\u5c07\u6539\u9020\u5f8c\u7684T\u7d30\u80de\u64f4\u589e\u3001\u56de\u8f38\u81f3\u60a3\u8005\u9ad4\u5167\u3002 \u4f46\u662f\uff0c\u5728\u9762\u5c0d\u5be6\u9ad4\u7624\u6642\uff0cCAR-T\u7642\u6cd5\u5b58\u5728\u4e00\u500b\u7f3a\u9ede\uff0c\u90a3\u5c31\u662f\u9032\u5165\u5be6\u9ad4\u7624\u4e2d\u7684T\u7d30\u80de\u53ef\u80fd\u6703\u56e0\u70ba\u4e00\u7a2e\u300cT\u7d30\u80de\u8870\u7aed\u300d\uff08T cell exhaustion\uff09\u7684\u73fe\u8c61\u800c\u505c\u6b62\u5de5\u4f5c\u3002 \u800c\u70ba\u4f55\u6703\u6709\u300cT\u7d30\u80de\u8870\u7aed\u300d\u7684\u73fe\u8c61\u767c\u751f\u5462\uff1f \u7f8e\u570b\u52a0\u5dde\u514d\u75ab\u5b78\u7814\u7a76\u6240\uff08LJI\uff09\u767c\u8868\u5728\u300aNature\u300b\u671f\u520a\u4e0a\u7684\u7814\u7a76\u767c\u73fe\uff0c\u4e00\u7a2e\u540d\u70baNr4a \u7684\u8f49\u9304\u56e0\u5b50\u5bb6\u65cf\uff0c\u5728\u9020\u6210T\u7d30\u80de\u8870\u7aed\u7684\u904e\u7a0b\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002 \u4ee5\u7f79\u764c\u5c0f\u9f20\u70ba\u9032\u884c\u5be6\u9a57\u767c\u73fe\uff0c\u7576\u7f3a\u4e4fNr4a\u8f49\u9304\u56e0\u5b50\u6642\uff0cCAR-T\u6cbb\u7642\u6548\u679c\u66f4\u4f73\uff0c\u53ef\u4ee5\u8b93\u816b\u7624\u9ad4\u7a4d\u6e1b\u5c0f\uff0c\u60a3\u764c\u5c0f\u9f20\u751f\u5b58\u7387\u63d0\u9ad8\u3002 \u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u7576T\u7d30\u80de\u9762\u81e8\u6162\u6027\u75c5\u6bd2\u611f\u67d3\u6642\uff0cNr4a\u7684\u542b\u91cf\u6703\u4e0a\u5347\u3002\u800c\u66b4\u9732\u65bc\u6162\u6027\u75c5\u6bd2\u6297\u539f\u6642\u9593\u6108\u4e45\uff0cT\u7d30\u80de\u5c31\u6703\u51fa\u73fe\u300c\u75b2\u5026\u300d\u7684\u72c0\u6cc1\uff0c\u6700\u5f8c\u5c31\u662f\u8b8a\u6210\u300c\u505c\u6b62\u5de5\u4f5c\u300d\u3002 \u9019\u9805\u7814\u7a76\u78ba\u8a8d\u4e86\u9020\u6210T\u7d30\u80de\u8870\u7aed\u7684\u95dc\u9375\u56e0\u5b50\uff0c\u96d6\u7136\u76ee\u524d\u7121\u6cd5\u76f4\u63a5\u61c9\u7528\u65bcCAR-T\u6cbb\u7642\u5be6\u9ad4\u7624\u7684\u81e8\u5e8a\u7814\u7a76\u4e2d\uff0c\u4f46\u7b49\u65bc\u662f\u89e3\u958b\u4e86\u4e00\u500b\u514d\u75ab\u5b78\u8b0e\u5718\uff0c\u4e5f\u70ba\u79d1\u5b78\u5bb6\u5011\u63d0\u4f9b\u4e86\u4e00\u500b\u8a2d\u8a08\u66f4\u597d\u6297\u764c\u7b56\u7565\u7684\u65b0\u7dda\u7d22\u3002<\/p>\n","protected":false},"author":2,"featured_media":3779,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-3778","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-medical-knowledge"],"aioseo_notices":[],"views":11,"_links":{"self":[{"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/posts\/3778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/comments?post=3778"}],"version-history":[{"count":1,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/posts\/3778\/revisions"}],"predecessor-version":[{"id":3780,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/posts\/3778\/revisions\/3780"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/media\/3779"}],"wp:attachment":[{"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/media?parent=3778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/categories?post=3778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/tags?post=3778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}