{"id":4073,"date":"2026-03-21T02:23:09","date_gmt":"2026-03-21T02:23:09","guid":{"rendered":"https:\/\/sodlike.sk-ads.com\/?p=4073"},"modified":"2026-03-24T02:25:15","modified_gmt":"2026-03-24T02:25:15","slug":"antioxidant-journey-understanding-free-radicals-part-2","status":"publish","type":"post","link":"https:\/\/sodlike.sk-ads.com\/index.php\/2026\/03\/21\/antioxidant-journey-understanding-free-radicals-part-2\/","title":{"rendered":"\u6297\u6c27\u5316\u4e4b\u65c5-\u8a8d\u8b58\u81ea\u7531\u57fa(2)"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u9ad4\u5167\u5929\u7136\u6297\u6c27\u5316\u9632\u79a6\u7cfb\u7d71\u5247\u5305\u62ec\uff1aSOD\u3001 Catalase\u3001GSH-Pox \u4e09\u7a2e\u6297\u6c27\u5316\u9176\u5171\u540c\u904b\u4f5c\u00a0\u00a0\u00a0\u00a0
SOD \u5148\u5c07 O2\u2027- \u6b67\u5316\u6210H2O2\uff0c\u7136\u5f8c\u85c9\u7531Catalase \u8207 GSH-Pox \u5c07 H2O2 \u8207\u904e\u6c27\u5316\u8102\u8cea\u4ee3\u8b1d\u89e3\u6bd2\u3002

\u4f46\u7576\u5e74\u9f61\u8d85\u904e30\u6b72\uff0c\u9ad4\u5167\u88fd\u9020\u6297\u6c27\u5316\u9176\u7684\u80fd\u529b\u6703\u4e0b\u964d\uff01\u8eab\u9ad4\u4fbf\u9010\u6f38\u8001\u5316\u3002<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u7576\u9ad4\u5167\u7e3d\u6297\u6c27\u5316\u80fd\u529b(\u9ad4\u5167\u5929\u7136\u6297\u6c27\u5316\u9632\u79a6\u7cfb\u7d71\u53ca\u5f9e\u98df\u7269\u4e2d\u6240\u88dc\u5145\u7684\u6297\u6c27\u5316\u7269\u8cea)\u7121\u6cd5\u6e05\u9664\u591a\u9918\u6c27\u81ea\u7531\u57fa\u6642\uff0c<\/strong><\/p>\n\n\n\n

\u8eab\u9ad4\u4fbf\u9762\u81e8\u6c27\u5316\u58d3\u529b\u5371\u6a5f<\/u>\u00a0\u3002

\u9019\u5c31\u662f\u75be\u75c5\u7684\u8d77\u6e90\uff0c\u8001\u5316\u7684\u524d\u594f\u3002

\u904e\u91cf\u6c27\u81ea\u7531\u57fa\u6703\u653b\u64ca\u6b63\u5e38\u7d30\u80de\u4e4b\u7d30\u80de\u819c\u3001\u86cb\u767d\u8cea\u3001DNA\uff0c \u5c0e\u81f4\u7d30\u80de\u9593\u8a0a\u606f\u50b3\u905e\u7570\u5e38\u6216\u58de\u6b7b\uff0c
\u751a \u81f3\u9020\u6210DNA\u7a81\u8b8a\u3002

\u6700\u5f8c\u6703\u5c0e\u81f4\u514d\u75ab\u529f\u80fd\u7570\u5e38\u3001\u52d5\u8108\u786c\u5316\u3001\u7522\u751f\u5404\u7a2e\u75be\u75c5<\/u>\u3001\u8001\u5316\u73fe\u8c61\u53ca\u764c\u75c7<\/u>\u3002\u00a0<\/strong><\/p>\n\n\n\n

Med Biol<\/em><\/strong>.,62(5):285-9, 1984;\u00a0
Am J Clin Nutr<\/em><\/strong>., 37(1):5-7, 1983<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u7f8e\u570b\u570b\u5bb6\u9ad8\u9f61\u8001\u5316\u7814\u7a76\u4e2d\u5fc3\u7684\u67ef\u7279\u62c9 (R. G. Cutler) \u535a\u58eb\u66fe\u505a\u4e86\u4e00\u500b\u9577\u671f\u6709\u7cfb\u7d71\u7684\u7814\u7a76\uff0c
\u4ed6\u91dd\u5c0d\u4eba\u9ad4\u6b7b\u4ea1\u5f8c\u5728\u5404\u5668\u5b98\u4e2d\u7684\u6297\u6c27\u5316\u9176\u53ca\u6297\u6c27\u5316\u7269\u8cea\u7684\u542b\u91cf\u505a\u4e86\u5206\u6790\u5f8c\uff0c
\u767c\u73fe\u4eba\u7684\u58fd\u547d\u8207\u9ad4\u5167\u7684\u6297\u6c27\u5316\u7269\u8cea\u7684\u542b\u91cf\u6210\u6b63\u6bd4<\/u>\u3002<\/strong>
<\/p>\n\n\n\n

\u00a0Am J Clin Nutr<\/em>.,53:373S-379S., 1991<\/strong>

\u800c\u5728\u65e5\u5e38\u98f2\u98df\u4e2d\u6240\u651d\u53d6\u7684\u6297\u6c27\u5316\u7269\u8cea\u8207\u6c27\u81ea\u7531\u57fa\u5728\u6025\u901f\u4f5c\u7528\u5f8c\uff0c\u5fc5\u9808\u4e0d\u6703\u5f15\u8d77\u5176\u4ed6\u4e0d\u826f\u7684\u5f8c\u679c<\/u>\u3002<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

1.\u55ae\u4e00\u539f\u6599\u8403\u53d6\u6216\u55ae\u4e00\u5316\u5b78\u6210\u4efd\u6297\u6c27\u5316\u7269\uff1a\u9577\u671f\u4f7f\u7528\u53ef\u80fd\u6703\u7834\u58de\u6046\u5b9a\u6027(\u985e\u4f3c\u85e5\u7269\u526f\u4f5c\u7528)

2.\u7d9c\u5408\u7dad\u4ed6\u547d\u578b\uff1a\u6548\u679c\u4e0d\u660e\u78ba\uff0c\u751a\u81f3\u5c0d\u8eab\u9ad4\u6709\u5bb3

3.\u4e94\u7a40\u96dc\u7ce7\u6216\u852c\u679c\u6fc3\u7e2e\u88fd\u5291\uff1a\u4e0d\u5982\u5747\u8861\u98f2\u98df

4.me-too\u00a0\u4e82\u69cd\u6253\u9ce5\u578b\uff1a\u542b\u4e00\u5927\u5806\u7576\u4e0b\u6d41\u884c\u7684\u7d20\u6750\uff0c\u4f46\u7121\u6cd5\u78ba\u5be6\u8b49\u660e\u7522\u54c1\u672c\u8eab\u529f\u6548\u771f\u5be6\u6027\uff0c
\u00a0 \u00a0\u91ab\u85e5\u754c\u7a31\u4e4b\u9ad8\u5229\u6f64\u5473\u7d20\u85e5\u00a0(\u4ec0\u9ebc\u90fd\u6709\u537b\u6c92\u6709\u4ec0\u9ebc\u6548\uff01)

5.\u5929\u7136\u539f\u6750\u6599\u751f\u7269\u79d1\u6280\u767c\u9175\uff1a\u64c1\u6709\u5c08\u5229\u8b49\u660e\u4e26\u901a\u904e\u5b89\u5168\u6027\u8a55\u4f30\uff0c\u66fe\u520a\u8f09\u5728\u91ab\u5b78\u671f\u520a\u8005\u70ba\u4f73<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

1.\u62bd\u7159\u6216\u66b4\u9732\u65bc\u77f3\u68c9\u4e4b\u5de5\u4f5c\u74b0\u5883\u8005\uff0c\u6bcf\u65e5\u88dc\u5145\u03b2-carotene 30mg\uff0cVit A 25000U\uff0c\u80ba\u764c\u7f79\u60a3\u7387
\u00a0\u00a0 \u63d0\u9ad8 28 %\uff0c\u6b7b\u4ea1\u7387\u63d0\u9ad8 17 %\u3002 N. Engl. J. Med<\/em><\/strong>.,<\/em>334:1150-55,1996

2.Vit C \u5728 \u6c27\u5316\u58d3\u529b (\u5167\u751f\u6027\u6e38\u96e2\u9435\u5b58\u5728\u4e0b)\u00a0\u53ef\u4fc3\u4f7f\u904e\u6c27 \u5316\u8102\u8cea ( lipid hydroperoxide ) \u7522\u751f
\u00a0\u00a0 \u57fa\u56e0\u6bd2\u6027\u7269\u8cea(genotoxins)\uff0c\u640d\u5bb3DNA \uff0c \u8a98\u767c\u764c\u75c7\u3002 Science<\/em><\/strong>, 292(5524):2083-6, 2001

3.\u63d0\u9ad8\u816b\u7624\u7d30\u80de\u5167 Vit C \u4e4b\u542b\u91cf\uff0c\u53ef\u80fd\u6709\u52a9\u65bc\u816b\u7624\u7d30\u80de\u4e4b \u6210\u9577\u53ca\u589e\u5f37\u816b\u7624\u7d30\u80de\u62b5\u6297\u56e0\u5316\u5b78
\u00a0\u00a0\u00a0\u7642\u6cd5\u53ca\u653e\u5c04\u7642\u6cd5\u6240\u7522\u751f\u4e4b\u6c27\u5316\u58d3\u529b\uff0c\u4e0d\u5229\u65bc\u764c\u75c7\u6cbb\u7642\u3002 Cancer Res<\/em><\/strong>., 59:4555-58, 1999

4.\u51a0\u5fc3\u75c5\u60a3\u4f75\u670d\u5e38\u7528\u6297\u6c27\u5316\u7269( Vit A\u3001C \u3001 E \u3001 Se \u3001\u00a0\u03b2<\/em>\u00a0\u80e1\u863f\u8514\u7d20)\u6703\u6e1b\u5c11\u9ad4\u5167\u597d\u7684\u81bd\u56fa\u9187
\u00a0\u00a0\u00a0(HDL)\u00a0\uff0c\u964d\u4f4e\u50b3\u7d71\u964d\u81bd\u56fa\u9187\u85e5\u7269\u7684\u6548\u679c\uff0c\u800c\u589e\u52a0\u4e2d\u98a8\u548c\u5fc3\u808c\u6897\u585e\u7684\u6a5f\u7387\u3002 N.Engl.J.Med<\/em><\/strong>., 345(22):1583-92,2001

5.\u6bcf\u5929\u670d\u7528\u8d85\u904e 400 IU Vit E \u7684\u4eba\uff0c\u6bd4\u5b8c\u5168\u6c92\u6709\u88dc\u5145\u7684 \u4eba\uff0c\u6b7b\u4ea1\u7387\u8d85\u904e\u00a0\u00a0 10%\uff0c\u800c\u4efb\u4f55\u5316\u5b78
\u00a0\u00a0\u00a0\u7269\u8cea\uff0c\u53ea\u8981\u9577\u671f\u4f7f\u7528 \u4e26\u8d85\u904e\u4e00\u5b9a\u91cf\uff0c\u90fd\u5b58\u5728\u8457\u98a8\u96aa\u3002

\u00a0\u00a0\u88dc\u5145\u8449\u9178\u3001\u7dad\u751f\u7d20 A.C.E\u53ca\u03b2\u00a0<\/em>\u80e1\u863f\u8514\u7d20\u6216Se \u5143\u7d20\u7121\u6cd5\u9810\u9632\u4e2d\u98a8\u3001\u5fc3\u81df\u75c5\u6216\u764c\u75c7\uff0c\u5c0d\u7cd6\u5c3f\u75c5\u60a3\u8005
\u00a0\u00a0\u00a0\u4ea6\u7121\u6cd5\u9810 \u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u964d\u4f4e\u6b7b\u4ea1\u7387\u3002\u00a0\u00a0\u4f46\u651d\u53d6\u5bcc\u542b\u6297\u6c27\u5316\u7269\u98df\u7269\uff0c\u53ef\u964d\u4f4e\u7f79\u60a3\u4e0a\u8ff0\u75be\u75c5\u4e4b\u98a8\u96aa\u00a0\u3002<\/p>\n\n\n\n

Ann. Inter. Med<\/em><\/strong>., 139(1):51-70,2003;\u00a0\u00a0BMJ<\/em><\/strong>.,337:a1840,2008;
JAMA<\/em><\/strong>., 300(18):2123-33,2008;\u00a0Lancet<\/strong><\/em>,364:121928,2004;\u00a0<\/em>
Arch. Inter. Med<\/strong><\/em>., 164(14):1552-6,2004;
Ann. Inter. Med<\/em><\/strong>., 142(1):37-46,2005;
JAMA<\/em><\/strong>.,<\/em>\u00a02009;301(1):(doi:10.1001\/jama.2008.862.,863.,864);
ACCR<\/strong><\/em>(\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703),Nov.16,2008;
J. Natl. Cancer Inst<\/em><\/strong>.,101(1):14-23,2009\u00a0<\/p>\n\n\n\n

\u552f\u6709\u88dc\u5145\u5177\u5099\u6e05\u9664O2-\u2022<\/strong>\u53ca\u00a0<\/strong>\u2022<\/strong>OH\u81ea\u7531\u57fa\u3001\u6e05\u9664\u904e\u6c27\u5316\u8102\u8cea\u3001\u5177\u975e\u6bd2\u6027\u4e4b\u5167\u751f\u6027\u9435\u96e2\u5b50\u87af\u5408\u4f5c\u7528\u3001
\u5177\u4fdd\u8b77DNA\u529f\u6548\u4ee5\u53ca\u80fd\u63d0\u9ad8GSH\u542b\u91cf\u4e4b\u5b8c\u6574\u6297\u6c27\u5316\u7269\uff0c\u624d\u80fd\u7dad\u6301\u9ad4\u5167\u6297\u6c27\u5316\u512a\u52e2 \uff0c
\u907f\u514d\u6c27\u5316\u5371\u6a5f\u53ca\u7d44\u7e54\u53d7 \u50b7\u3001\u611f\u67d3\u3001\u767c\u708e\u4e8c\u6b21\u50b7\u5bb3\u4f75\u767c\u75c7\u4e4b\u9032\u884c\u3002
\u5982\u6b64\u624d\u80fd\u9072\u7de9\u8001\u5316\uff0c\u5ef6\u9577\u4eba\u9ad4\u5404\u5668\u5b98\u7684\u6548\u80fd\u671f\u9650\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

1.\u5b8c\u6574\u6297\u6c27\u5316\u7269: raffinee <\/strong><\/em>\u5177\u5099
   A.\u6e05\u9664\u6216\u4e2d\u548c O2-\u2022<\/strong>\u3001\u2022<\/strong>OH\u3001L\u2022<\/strong>\u3001LO \u2022<\/strong>\u3001LOO\u2022<\/strong> \u7b49\u81ea\u7531\u57fa\u80fd\u529b<\/p>\n\n\n\n

   B.\u87af\u5408\u5167\u751f\u6027\u9435\u96e2\u5b50\u3001\u7d42\u6b62\u8102\u8cea\u81ea\u7531\u57fa\u9023\u9396\u53cd\u61c9<\/p>\n\n\n\n

   C. raffinee<\/em><\/strong> \u80fd\u63d0\u9ad8GSH-Pox\u6d3b\u6027\uff0c\u5c07\u904e\u6c27\u5316\u8102\u8cea\u4ee3\u8b1d\u89e3\u6bd2\uff0c\u6539\u5584\u5fae\u5faa\u74b0 
       raffinee<\/em><\/strong> \u80fd\u6709\u6548\u907f\u514d\u6c27\u5316\u58d3\u529b\u9020\u6210\u4e4b\u4e8c\u6b21\u50b7\u5bb3\u5371\u6a5f\u3002<\/p>\n\n\n\n

2.\u5177\u4fdd\u8b77DNA\u4f5c\u7528\uff1a
  \ufe5d8-OHdG\ufe5e\u662fDNA\u53d7\u6c27\u5316\u50b7\u5bb3\u7684\u751f\u5316\u6307\u6a19\uff0c\u8207\u7d30\u80de\u7a81\u8b8a\u3001\u81f4\u764c\u53ca\u8001\u5316\u904e\u7a0b\u6709\u6975\u5927\u4e4b\u95dc\u806f\u6027\u3002
   raffinee <\/em><\/strong>\u80fd\u964d\u4f4e\u9ad4\u5167\ufe5d8-OHdG\ufe5e\uff0c\u5177\u4fdd\u8b77DNA\u4f5c\u7528\uff0c\u6709\u52a9\u65bc\u7d30\u80de\u4fee\u8b77\u53ca\u9810\u9632\u764c\u75c7\u3001\u6297\u8870\u5ef6\u8001<\/p>\n\n\n\n

3.\u7dad\u6301\u6297\u6c27\u5316\u7db2\u8def\u7cfb\u7d71\u7684\u904b\u4f5c\uff1a<\/p>\n\n\n\n

   raffinee<\/em><\/strong> \u80fd\u63d0\u9ad8\u9ad4\u5167Glutathione(GSH\uff0c\u9ea9\u80f1\u7518\u80bd)\u6fc3\u5ea6\u3002
   GSH\u53ef\u5e6b\u52a9\u809d\u81df\u89e3\u6bd2\uff0c\u5f37\u5065\u514d\u75ab\u7cfb\u7d71\u529f\u80fd\uff0c\u6709\u52a9\u65bc\u86cb\u767d\u8cea\u7684\u88fd\u9020\u53ca\u9084\u539f\u5176\u4ed6\u5df2\u88ab\u6c27\u5316\u7684\u6297\u6c27\u5316\u7269\uff0c
   \u4ee5\u7dad\u6301\u6297\u6c27\u5316\u7db2\u8def\u7cfb\u7d71\u7684\u904b\u4f5c\u3002<\/p>\n\n\n\n

   \u203b\u9ad4\u5167\ufe5dGSH\ufe5e\u2193\uff0c\u662f\u75be\u75c5\u53ca\u6b7b\u4ea1\u7684\u524d\u5146\u3002
   \u63d0\u9ad8\u809d\u81dfGSH\u542b\u91cf\u53ef\u589e\u5f37\u9577\u671f\u670d\u85e5\u7684\u6162\u6027\u75c5\u60a3\u809d\u81df\u89e3\u6bd2\u80fd\u529b\uff0c\u907f\u514d\u624b\u8853\u5f8c\u53ca\u91cd\u75c7\u4f4f\u9662
   \u75c5\u60a3\u56e0\u9662\u5167\u611f\u67d3\u6240\u9020\u6210 \u6c27\u5316\u58d3\u529b\u4e4b\u4e8c\u6b21\u50b7\u5bb3\u5371\u6a5f\uff08\u6557\u8840\u75c7\u3001\u5fc3\u80ba\u8870\u7aed\uff09\u3002<\/p>\n\n\n\n

  \u203b\u4e00\u822c\u5e02\u552e\u55ae\u4e00\u539f\u6599\u8403\u53d6\u6216\u55ae\u4e00\u6210\u4efd\u6297\u6c27\u5316\u7269\uff0c\u56e0\u4e0d\u53ef\u80fd \u5177\u5099\u6297\u6c27\u5316\u512a\u52e2\uff0c\u6545\u7121\u6cd5\u5b8c\u6574
      \u514b\u670d\u5404\u7a2e\u6c27\u5316\u58d3\u529b\u5371\u6a5f \ufe57<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u9ad4\u5167\u5929\u7136\u6297\u6c27\u5316\u9632\u79a6\u7cfb\u7d71\u5247\u5305\u62ec\uff1aSOD\u3001 Catalase\u3001GSH-Pox \u4e09\u7a2e\u6297\u6c27\u5316\u9176\u5171\u540c\u904b\u4f5c\u00a0\u00a0\u00a0\u00a0SOD \u5148\u5c07 O2\u2027- \u6b67\u5316\u6210H2O2\uff0c\u7136\u5f8c\u85c9\u7531Catalase \u8207 GSH-Pox \u5c07 H2O2 \u8207\u904e\u6c27\u5316\u8102\u8cea\u4ee3\u8b1d\u89e3\u6bd2\u3002 \u4f46\u7576\u5e74\u9f61\u8d85\u904e30\u6b72\uff0c\u9ad4\u5167\u88fd\u9020\u6297\u6c27\u5316\u9176\u7684\u80fd\u529b\u6703\u4e0b\u964d\uff01\u8eab\u9ad4\u4fbf\u9010\u6f38\u8001\u5316\u3002 \u7576\u9ad4\u5167\u7e3d\u6297\u6c27\u5316\u80fd\u529b(\u9ad4\u5167\u5929\u7136\u6297\u6c27\u5316\u9632\u79a6\u7cfb\u7d71\u53ca\u5f9e\u98df\u7269\u4e2d\u6240\u88dc\u5145\u7684\u6297\u6c27\u5316\u7269\u8cea)\u7121\u6cd5\u6e05\u9664\u591a\u9918\u6c27\u81ea\u7531\u57fa\u6642\uff0c \u8eab\u9ad4\u4fbf\u9762\u81e8\u6c27\u5316\u58d3\u529b\u5371\u6a5f\u00a0\u3002 \u9019\u5c31\u662f\u75be\u75c5\u7684\u8d77\u6e90\uff0c\u8001\u5316\u7684\u524d\u594f\u3002 \u904e\u91cf\u6c27\u81ea\u7531\u57fa\u6703\u653b\u64ca\u6b63\u5e38\u7d30\u80de\u4e4b\u7d30\u80de\u819c\u3001\u86cb\u767d\u8cea\u3001DNA\uff0c \u5c0e\u81f4\u7d30\u80de\u9593\u8a0a\u606f\u50b3\u905e\u7570\u5e38\u6216\u58de\u6b7b\uff0c\u751a \u81f3\u9020\u6210DNA\u7a81\u8b8a\u3002 \u6700\u5f8c\u6703\u5c0e\u81f4\u514d\u75ab\u529f\u80fd\u7570\u5e38\u3001\u52d5\u8108\u786c\u5316\u3001\u7522\u751f\u5404\u7a2e\u75be\u75c5\u3001\u8001\u5316\u73fe\u8c61\u53ca\u764c\u75c7\u3002\u00a0 Med Biol.,62(5):285-9, 1984;\u00a0 Am J Clin Nutr., 37(1):5-7, 1983 \u7f8e\u570b\u570b\u5bb6\u9ad8\u9f61\u8001\u5316\u7814\u7a76\u4e2d\u5fc3\u7684\u67ef\u7279\u62c9 (R. 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