{"id":4092,"date":"2026-03-21T03:08:51","date_gmt":"2026-03-21T03:08:51","guid":{"rendered":"https:\/\/sodlike.sk-ads.com\/?p=4092"},"modified":"2026-03-24T02:25:01","modified_gmt":"2026-03-24T02:25:01","slug":"antioxidant-journey-understanding-free-radicals-part-1","status":"publish","type":"post","link":"https:\/\/sodlike.sk-ads.com\/index.php\/2026\/03\/21\/antioxidant-journey-understanding-free-radicals-part-1\/","title":{"rendered":"\u6297\u6c27\u5316\u4e4b\u65c5-\u8a8d\u8b58\u81ea\u7531\u57fa(1)"},"content":{"rendered":"\n

\u524d\u8a00
\u6c27\u81ea\u7531\u57fa\u662f\u4eba\u9ad4\u5728\u6c27\u5316\u4ee3\u8b1d\u904e\u7a0b\u53ca\u81ea\u7136\u9632\u79a6\u7cfb\u7d71\u4e2d\uff0c\u6240\u7522\u751f\u7684\u9ad8\u5ea6\u6d3b\u6027\u7269\u8cea\u3002
\u904e\u91cf\u7684\u6c27\u81ea\u7531\u57fa\uff0c\u6703\u653b\u64ca\u9ad4\u5167\u7d30\u80de\u819c\u4e0d\u98fd\u548c\u8102\u80aa\u9178\uff0c\u5f62\u6210\u904e\u6c27\u5316\u8102\u8cea\uff0c\u4e5f\u6703\u653b\u64ca\u9ad4\u5167\u86cb\u767d\u8cea\u53ca DNA\uff0c
\u5c0e\u81f4\u7d30\u80de\u7834\u58de\u3001\u6b7b\u4ea1\uff0c\u7522\u751f\u5404\u7a2e\u75be\u75c5\u3001\u8001\u5316\u73fe\u8c61\u53ca\u764c\u75c7\u3002
\u6839\u64da\u91ab\u5b78\u7814\u7a76\u5831\u544a\uff0c\u73fe\u4ee3\u6210\u4eba\u75c5\u4e2d\u670985% \u8207\u6c27\u81ea\u7531\u57fa\u548c\u904e\u6c27\u5316\u8102\u8cea\u6709\u95dc\u3002
<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u5177\u7368\u7acb\u4e0d\u6210\u5c0d\u96fb\u5b50\u7684\u539f\u5b50\u3001\u5206\u5b50\u6216\u96e2\u5b50
       ex\uff1aH\u2027\u3001 \u2027OH \u3001 O2–<\/strong>\u2027\u3001HO2\u2027\u3001NO\u3001NO2<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u6c27\u6c23\u5728\u9ad4\u5167\u4ee3\u8b1d\u4e4b\u5f8c\u6240\u884d\u751f\u51fa\u6d3b\u6027\u9ad8\u3001\u653b\u64ca\u6027\u5f37\u7684\u6c27\u6c23\u5316\u5408\u7269\u3002\u4ea6\u7a31\u70ba\u6c27\u81ea\u7531\u57fa(oxygen radicals)
       ex\uff1a1<\/strong>O2<\/strong>\u3001O2–<\/strong>\u2027\u3001\u2027OH\u3001H2O2<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

  \u4e00. Biosynthesis  \u751f\u7269\u5408\u6210(\u56e0\u9ad4\u5167\u9808\u8981\u800c\u7531\u80fa\u57fa\u9178\u5408\u6210)
 <\/p>\n\n\n\n

                                              NOS
O2 + L-Arginine (L-\u7cbe\u80fa\u9178)  \u2500\u2500\u2500\u2192  NO + L-Citruline<\/p>\n\n\n\n

              \u203b NO(\u4e00\u6c27\u5316\u6c2e\u81ea\u7531\u57fa)\u4e4b\u5f62\u6210\uff0c\u9808\u8981 L-\u7cbe\u80fa\u9178\u53ca NOS \u4e4b\u53c3\u8207\u5354\u52a9<\/p>\n\n\n\n

             NOS(\u4e00\u6c27\u5316\u6c2e\u5408\u6210\u9176)\u4e4b\u7a2e\u985e\uff1a
             1. \u7d44\u6210\u9175\u7d20(constitutive NOS, cNOS)
                nNOS\uff1a\u5927\u591a\u5b58\u5728\u65bc\u795e\u7d93\u7cfb\u7d71(\u8a0a\u606f\u50b3\u905e)
                eNOS\uff1a\u5927\u591a\u5b58\u5728\u65bc\u8840\u7ba1\u5167\u76ae(\u9b06\u5f1b\u5e73\u6ed1\u808c\u3001\u8840\u7ba1)

             2. \u8a98\u767c\u9175\u7d20(inducible NOS, iNOS)
                 \u5927\u591a\u5b58\u65bc\u514d\u75ab\u7cfb\u7d71(\u6e05\u9664\u7570\u7269) \uff0c\u9808\u8981\u6642\uff0c\u6fc3\u5ea6\u6703\u589e\u52a0 <\/p>\n\n\n\n

Pharmacol. Rev<\/strong><\/em>., 43:109,1991
 <\/p>\n\n\n\n

       \u4e8c.Metabolism \u65b0\u9673\u4ee3\u8b1d\u7522\u7269\uff1a   
             \u7531\u6c27\u6c23(O2) \u5728\u9ad4\u5167\u65b0\u9673\u4ee3\u8b1d\u904e\u7a0b\u4e2d\u6240\u7522\u751f\uff0c\u5305\u62ec O2-\u2027 \u8d85\u6c27\u81ea\u7531\u57fa\u9670\u96e2\u5b50\u53ca
             \u2027OH \u7fa5\u57fa\u81ea\u7531\u57fa (\u6c2b\u6c27\u81ea\u7531\u57fa)
 <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

       \u4e09.\u5916\u4f86\u7269\u8cea\u3001\u74b0\u5883\u6c61\u67d3\u7684\u9644\u5e36\u7269   
             \u5305\u62ec\uff1a\u6c34\u8cea\u3001\u7a7a\u6c23 (\u6c7d\u3001\u6a5f\u8eca\uff0c\u5de5\u5ee0\u5ee2\u6c23\u7b49) \u4ee5\u53ca\u8f3b\u5c04\u6c61\u67d3\u3001\u67d0\u4e9b\u98df\u7269\u3001 \u85e5\u7269\u3001\u8fb2\u85e5\u6216\u98df\u54c1\u6dfb
             \u52a0\u7269(\u4fdd\u5b58\u5291\u3001\u5851\u5316\u5291\u3001\u9999\u6599\u3001\u9632\u8150\u5291\u7b49)\u3002
             \u9019\u4e9b\u7269\u8cea\u5728\u9ad4\u5167\u4ee3\u8b1d\u904e\u7a0b\u4e2d\u5bb9\u6613\u5f62\u6210\u81ea\u7531\u57fa\uff0c\u4e26\u80fd\u5f15\u767c\u57fa\u56e0\u7a81\u8b8a\u800c\u81f4\u764c\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u4e00. \u9069\u91cf\u81ea\u7531\u57fa\u53c3\u8207\u5404\u7a2e\u751f\u7406\u6a5f\u80fd\u904b\u4f5c\uff0c\u7dad\u6301\u9ad4\u5167\u6046\u5b9a\u6027 
\u4e00. a.\u5728\u514d\u75ab\u529f\u80fd\u4e2d\uff0c\u626e\u6f14\u6bba\u83cc\u3001\u6e05\u9664\u7570\u7269\u53ca\u53d7\u640d\u7d44\u7e54\u7684\u89d2\u8272
\u4e00\u4e00. ex\uff1a \u2027OH \uff0cO2–<\/strong>\u2027 \uff0cNO
\u4e00. b.\u4eba\u9ad4\u795e\u7d93\u7cfb\u7d71\u50b3\u905e\u8a0a\u606f\u53ca\u8840\u7ba1\u5167\u76ae\u8abf\u63a7\u8840\u58d3\u7684\u5206\u5b50
\u4e00. \u4e00.ex\uff1aNO

\u4e8c. \u904e\u91cf\u81ea\u7531\u57fa\uff0c\u842c\u75c5\u4e4b\u6e90 (ex.\u6025\u3001\u6162\u6027\u767c\u708e\u53cd\u61c9)
                                        H+
\u4e00. NO\uff0bO2\u2027- \u2192 ONOO- \u2192\u2027OH\uff0bNO2\u2027 (\u6c27\u5316\u58d3\u529b\u4e0b\u9032\u884c)  
\u4e00. (\u203b  \u2027OH:\u6bd2\u6027\u6700\u5f37\u81ea\u7531\u57fa)<\/p>\n\n\n\n


  The American Journal  of  Surgery<\/em><\/strong> 161, 488-500, 1991;
Nature,<\/em><\/strong> 364:626~632, 1993.,  Annals<\/em><\/strong> of Internal<\/em><\/strong>  Medicine<\/em><\/strong>, 107, 526-545, 1987<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

1.\u7576\u7d44\u7e54\u53d7\u50b7\u3001\u611f\u67d3\u3001\u767c\u708e\u53ca\u7f3a\u8840\u518d\u704c\u6d41\u904e\u7a0b\u4e2d\uff0c\u5167\u751f\u6027\u9435\u6e38\u96e2\u51fa\u4f86\uff0c
   \u52a0\u901f Fenton R(\u82ac\u9813\u53cd\u61c9) \u53ca Harber-weiss R (\u54c8\u4f2f-\u9b4f\u6c0f\u53cd\u61c9)\u5f62\u6210\u2027OH
\u6c27\u5316\u58d3\u529b\u4e0b\uff0cNO\u2027 \u8207 O2-\u2027\u6613\u5f62\u6210 ONOO-\uff0c\u4e26\u9032\u4e00\u6b65\u4ee3\u8b1d\u6210 \u2027OH \u3002
\u56e0\u6b64\uff0c\u5728\u7d44\u7e54\u53d7\u50b7\u3001\u611f\u67d3(\u75c5\u6bd2\u6216\u7d30\u83cc)\u3001\u767c\u708e\u53ca\u7f3a\u8840\u518d\u704c\u6d41\u904e\u7a0b\u4e2d\uff0c\u6613\u770b\u5230
\u9ad8\u6fc3\u5ea6\u4e4b ONOO- \u53ca \u2027OH\u3002

2.\u6c2b\u6c27\u81ea\u7531\u57fa\u2027OH\uff1a\u6700\u6bd2\u7684\u81ea\u7531\u57fa
   \u2027OH\u53ea\u8981\u4e00\u51fa\u73fe\uff0c\u99ac\u4e0a\u7834\u58de\u7d30\u80de\u819c\u4e0d\u98fd\u548c\u8102\u80aa\u9178( 10\u02c99\u79d2)\uff0c\u4e26\u9032\u4e00\u6b65\u7834\u58de
\u5468\u906d\u6b63\u5e38\u7d30\u80de.\u3001\u7d44\u7e54\u4e4b\u7d30\u80de\u819c\u3001\u86cb\u767d\u8cea\u3001DNA\uff0c\u9020\u6210\u539f \u672c\u75c5\u7076\u5468\u906d\u6b63\u5e38\u7d30\u80de\u3001
\u7d44\u7e54\u4e4b\u4e8c\u6b21\u50b7\u5bb3\u9023\u9396\u53cd\u61c9\u3002

3.\u4e8c\u6b21\u50b7\u5bb3\u6240\u9020\u6210\u4e4b\u6c27\u5316\u58d3\u529b\u5371\u6a5f\uff0c\u6703\u5c0e\u81f4\u514d\u75ab\u529f\u80fd\u7570\u5e38\u3001\u52d5\u8108\u786c\u5316\u3001\u5404\u7a2e
\u8001\u5316\u73fe\u8c61\u53ca\u764c\u75c7\u7522\u751f\u3002

4.\u7576\u611f\u67d3\u75c5\u6bd2\u6216\u7d30\u83cc\u6642\uff0c\u56e0\u904e\u5ea6\u514d\u75ab\u53cd\u61c9\u6240\u9020\u6210\u4e4b\u4e8c\u6b21\u50b7\u5bb3\uff0c\u662f\u5c0e\u81f4\u5404\u7a2e
\u611f\u67d3\u4f75\u767c\u75c7(\u6557\u8840.\u75c7\u548c\u5fc3\u80ba\u8870\u7aed)\u6216\u9020\u6210\u591a\u91cd\u5668\u5b98\u8870\u7aed\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u75be\u75c5(\u7d44\u7e54\u53d7\u50b7\u6216\u7d30\u83cc\u3001\u75c5\u6bd2\u3001\u5916\u4f86\u7269\u8cea\u5165\u4fb5)<\/p>\n\n\n\n

\u2192\u5728\u767c\u708e\u3001\u611f\u67d3\u7684\u4fee\u5fa9\u904e\u7a0b\u4e2d\uff0c\u514d\u75ab\u7cfb\u7d71\u91cb\u51fa\u5927\u91cf\u6c27\u81ea\u7531\u57fa\uff0c\u9664\u6bba\u6ec5\u75c5\u83cc\u3001
\u2192\u6e05\u9664\u5916\u4f86\u7570\u7269\u5916\uff0c\u4e26\u653b\u64ca\u5468\u906d\u6b63\u5e38\u7d30\u80de\u4e4b\u7d30\u80de\u819c\u3001\u86cb\u767d\u8cea\u3001DNA<\/p>\n\n\n\n

\u2192\u6d88\u8017\u9ad4\u5167\u6297\u6c27\u5316\u80fd\u529b\u8207 GSH\uff0c\u7522\u751f\u6c27\u5316\u58d3\u529b\u5371\u6a5f<\/p>\n\n\n\n

\u2192\u7d30\u80de\u906d\u53d7\u7834\u58de\u6216\u6b7b\u4ea1<\/p>\n\n\n\n

\u2192\u589e\u52a0\u8102\u8cea\u904e\u6c27\u5316\u9023\u9396\u53cd\u61c9\uff0c\u7522\u751f\u4e8c\u6b21\u50b7\u5bb3<\/p>\n\n\n\n

\u2192\u75c5\u60c5\u60e1\u5316\u3001\u611f\u67d3\u4f75\u767c\u75c7\uff0c\u6c27\u5316\u58d3\u529b\u6301\u7e8c\u589e\u9ad8<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

1. SOD(Superoxide dismutase)\u904e\u6c27\u5316\u7269\u6b67\u5316\u9176
                         SOD
   2O2\u00b7-\uff0b2H+ \u2500\u2500\u2500\u2192  H2O2\uff0b O2    

2. Catalase \u904e\u6c27\u5316\u6c2b\u9176
                   Catalase
   2 H2O2   \u2500\u2500\u2500\u2192  2 H2O + 1\/2 O2

3. GSH-Pox(Glutathione peroxidase)\u9ea9\u80f1\u7518\u80bd\u904e\u6c27\u5316\u9176
                          GSH-Pox
   H2O2 + 2GSH \u2500\u2500\u2500\u2192  GSSG + 2 H2O   

   \u203b\u4e0a\u8ff0\u4e09\u7a2e\u6297\u6c27\u5316\u9176\u7121\u6cd5\u53e3\u670d\u88dc\u5145\uff0c\u56e0\u70baSOD\u9019\u4e9b\u86cb\u767d\u8cea\u9175\u7d20\u6703\u88ab\u80c3\u9178\u7834\u58de\u800c\u5931\u53bb\u529f\u6548 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u524d\u8a00\u6c27\u81ea\u7531\u57fa\u662f\u4eba\u9ad4\u5728\u6c27\u5316\u4ee3\u8b1d\u904e\u7a0b\u53ca\u81ea\u7136\u9632\u79a6\u7cfb\u7d71\u4e2d\uff0c\u6240\u7522\u751f\u7684\u9ad8\u5ea6\u6d3b\u6027\u7269\u8cea\u3002\u904e\u91cf\u7684\u6c27\u81ea\u7531\u57fa\uff0c\u6703\u653b\u64ca\u9ad4\u5167\u7d30\u80de\u819c\u4e0d\u98fd\u548c\u8102\u80aa\u9178\uff0c\u5f62\u6210\u904e\u6c27\u5316\u8102\u8cea\uff0c\u4e5f\u6703\u653b\u64ca\u9ad4\u5167\u86cb\u767d\u8cea\u53ca DNA\uff0c\u5c0e\u81f4\u7d30\u80de\u7834\u58de\u3001\u6b7b\u4ea1\uff0c\u7522\u751f\u5404\u7a2e\u75be\u75c5\u3001\u8001\u5316\u73fe\u8c61\u53ca\u764c\u75c7\u3002\u6839\u64da\u91ab\u5b78\u7814\u7a76\u5831\u544a\uff0c\u73fe\u4ee3\u6210\u4eba\u75c5\u4e2d\u670985% \u8207\u6c27\u81ea\u7531\u57fa\u548c\u904e\u6c27\u5316\u8102\u8cea\u6709\u95dc\u3002 \u5177\u7368\u7acb\u4e0d\u6210\u5c0d\u96fb\u5b50\u7684\u539f\u5b50\u3001\u5206\u5b50\u6216\u96e2\u5b50       ex\uff1aH\u2027\u3001 \u2027OH \u3001 O2–\u2027\u3001HO2\u2027\u3001NO\u3001NO2 \u6c27\u6c23\u5728\u9ad4\u5167\u4ee3\u8b1d\u4e4b\u5f8c\u6240\u884d\u751f\u51fa\u6d3b\u6027\u9ad8\u3001\u653b\u64ca\u6027\u5f37\u7684\u6c27\u6c23\u5316\u5408\u7269\u3002\u4ea6\u7a31\u70ba\u6c27\u81ea\u7531\u57fa(oxygen radicals)       ex\uff1a1O2\u3001O2–\u2027\u3001\u2027OH\u3001H2O2   \u4e00. Biosynthesis  \u751f\u7269\u5408\u6210(\u56e0\u9ad4\u5167\u9808\u8981\u800c\u7531\u80fa\u57fa\u9178\u5408\u6210)                                                NOSO2 + L-Arginine (L-\u7cbe\u80fa\u9178)  \u2500\u2500\u2500\u2192  NO + L-Citruline               \u203b NO(\u4e00\u6c27\u5316\u6c2e\u81ea\u7531\u57fa)\u4e4b\u5f62\u6210\uff0c\u9808\u8981 L-\u7cbe\u80fa\u9178\u53ca NOS \u4e4b\u53c3\u8207\u5354\u52a9              NOS(\u4e00\u6c27\u5316\u6c2e\u5408\u6210\u9176)\u4e4b\u7a2e\u985e\uff1a             1. \u7d44\u6210\u9175\u7d20(constitutive NOS, cNOS)        […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-4092","post","type-post","status-publish","format-standard","hentry","category-antioxidant-journey"],"aioseo_notices":[],"views":29,"_links":{"self":[{"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/posts\/4092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/comments?post=4092"}],"version-history":[{"count":2,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/posts\/4092\/revisions"}],"predecessor-version":[{"id":4177,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/posts\/4092\/revisions\/4177"}],"wp:attachment":[{"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/media?parent=4092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/categories?post=4092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sodlike.sk-ads.com\/index.php\/wp-json\/wp\/v2\/tags?post=4092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}